Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase
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چکیده
منابع مشابه
Transglutaminase-catalyzed transamidation: a novel mechanism for Rac1 activation by 5-hydroxytryptamine2A receptor stimulation.
Transglutaminase (TGase)-induced activation of small G proteins via 5-hydroxytryptamine (HT)(2A) receptor signaling leads to platelet aggregation (Cell 115:851-862, 2003). We hypothesize that stimulation of 5-HT(2A) receptors in neurons activates TGase, resulting in transamidation of serotonin to a small G protein, Rac1, thereby constitutively activating Rac1. Using immunoprecipitation and immu...
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ates rapid Ca store release through the activation of InsP3 receptors (IP3R) in the endoplasmic reticulum (ER) membrane (Berridge et al., 2000). Following this initial Randen L. Patterson,1,6 Damian B. van Rossum,2,6 Diana L. Ford,2 Kenneth J. Hurt,1 Sun Sik Bae,3 Pann-Ghill Suh,3 Tomohiro Kurosaki,4 Ca store-release, external Ca enters through plasma Solomon H. Snyder,1,5 and Donald L. Gill2 m...
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We investigated the concentration- and Ca(2+)-dependent effects of CaM mutants, CaM(12) and CaM(34), in which Ca(2+)-binding to its N- and C-lobes was eliminated, respectively, on the Ca(V)1.2 Ca(2+) channel by inside-out patch clamp in guinea-pig cardiomyocytes. Both CaM(12) and CaM(34) (0.7-10muM) applied with 3mM ATP produced channel activity after "rundown". Concentration-response curves we...
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......................................................................................................................................... iii Acknowledgements ......................................................................................................................... v List of Figures and Tables...........................................................................................
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2010
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-010-1984-7